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Article

Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2007

Tian Chaorui, Ansari Mohammed Javeed I, Paez-Cortez Jesus, Bagley Jessamyn, Godwin Jonathan, Donnarumma Michela, Sayegh Mohamed H, Iacomini John

Abstract excerpt

We have previously shown that the development of type 1 diabetes (T1D) can be prevented in nonobese diabetic (NOD) mice by reconstitution with autologous hemopoietic stem cells retrovirally transduced with viruses encoding MHC class II I-A beta-chain molecules associated with protection from the disease. In this study we examined whether a blockade of the programmed death-1 (PD-1)-programmed death ligand-1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-2 Receptor alpha Subunit

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Source

Identifiers

PMID: 17982066
DOI: 10.4049/jimmunol.179.10.6762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy.PMID 17982066Read ↗

Prevention of type 1 diabetes by gene therapySemantic proximity Read ↗

NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.Semantic proximity Read ↗

Donor-derived CD8 <sup>+</sup> CD122 <sup>+</sup> Tregs generated in mixed donor chimeric NOD mice delete autoreactive T cellsSemantic proximity Read ↗

CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.Semantic proximity Read ↗

Bone marrow expressing a diabetes resistance MHC class II allele: diabetes deviation by chronic immune stimulation.Semantic proximity Read ↗

Prevention of type 1 diabetes with major histocompatibility complex-compatible and nonmarrow ablative hematopoietic stem cell transplants.Semantic proximity Read ↗

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.Semantic proximity Read ↗

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.Semantic proximity Read ↗

Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice.Semantic proximity Read ↗

MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.Semantic proximity Read ↗

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.Semantic proximity Read ↗

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.Semantic proximity Read ↗

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