Article

Donor-derived CD8 <sup>+</sup> CD122 <sup>+</sup> Tregs generated in mixed donor chimeric NOD mice delete autoreactive T cells

2026-03-22

Abstract excerpt

The establishment of mixed hematopoietic chimerism is a promising way to induce immune tolerance for islet replacement therapy and to treat the underlying autoimmunity in Type 1 diabetes (T1D). Mixed chimerism not only promotes effective thymic negative selection of autoreactive cells but also restores regulatory T cell (Treg) function and peripheral tolerance. In the current study, we determined that a novel clas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4423b523-8067-5070-befd-9b70a1aa1a30
DOI: 10.64898/2026.03.20.712252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Donor-derived CD8 <sup>+</sup> CD122 <sup>+</sup> Tregs generated in mixed donor chimeric NOD mice delete autoreactive T cellsDOI 10.64898/2026.03.20.712252Read

Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell FunctionSemantic proximity Read

Deletion of CD226 in Foxp3 <sup>+</sup> T cells Reduces Diabetes Incidence in Non-Obese Diabetic Mice by Improving Regulatory T Cell Stability and FunctionSemantic proximity Read

THE NOD MOUSE: A Model of Immune DysregulationSemantic proximity Read

Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions.Semantic proximity Read

CD38 defines a therapeutically targetable pathogenic T cell population for precision immunotherapy in autoimmune diabetesSemantic proximity Read

The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model.Semantic proximity Read

Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetesSemantic proximity Read

Single-cell RNA-seq reveals TCR clonal expansion and a high frequency of transcriptionally distinct double-negative T cells in NOD miceSemantic proximity Read

NOD mice and autoimmunity.Semantic proximity Read

Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy.Semantic proximity Read

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.Semantic proximity Read

TRAJ23 Gene Targeting as a Therapeutic Strategy for Type 1 Diabetes: Implications from NOD Mouse Model StudiesSemantic proximity Read