Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2005

Martinez Xavier, Kreuwel Huub T C, Redmond William L, Trenney Rebecca, Hunter Kara, Rosen Hugh, Sarvetnick Nora, Wicker Linda S, Sherman Linda A

Abstract excerpt

Although candidate genes controlling autoimmune disease can now be identified, a major challenge that remains is defining the resulting cellular events mediated by each locus. In the current study we have used NOD-InsHA transgenic mice that express the influenza hemagglutinin (HA) as an islet Ag to compare the fate of HA-specific CD8+ T cells in diabetes susceptible NOD-InsHA mice with that observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Islets of Langerhans

Share to Lymph Nodes

Share to Mice, Congenic

Share to Mice, Inbred NOD

Share to Pancreas

Source

Identifiers

PMID: 16034108
DOI: 10.4049/jimmunol.175.3.1677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.PMID 16034108Read ↗

Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.Semantic proximity Read ↗

MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.Semantic proximity Read ↗

TCR transgenic mice reveal the impact of type 1 diabetes loci on early and late disease checkpoints.Semantic proximity Read ↗

THE NOD MOUSE: A Model of Immune DysregulationSemantic proximity Read ↗

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.Semantic proximity Read ↗

Cellular mechanisms involved in experimental insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Understanding autoimmune diabetes: insights from mouse models.Semantic proximity Read ↗

Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain.Semantic proximity Read ↗

Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line.Semantic proximity Read ↗

Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Semantic proximity Read ↗

Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5.Semantic proximity Read ↗

A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.