Article
Bone marrow expressing a diabetes resistance MHC class II allele: diabetes deviation by chronic immune stimulation.
Novartis Foundation symposium - 1 Jan 2008
Reifsnyder Peter, Schott William, Pomerleau Darcy, Lessard Mark D, Soper Brian W, Leiter Edward H
Abstract excerpt
The major histocompatibility complex (MHC) of the type 1 diabetes-prone NOD mouse lacks a functional class II H2-Ea gene such that antigen presenting cells (APCs) are I-E null. Transgenic expression of Ea in NOD mice both restores I-E expression and confers complete protection from diabetes progression. Non-myeloablative neonatal transplantation of bone marrow cells from such I-E+ transgenic donors into NOD...
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