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Article

NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.

Diabetes - 1 Feb 2003

Pearson Todd, Markees Thomas G, Wicker Linda S, Serreze David V, Peterson Laurence B, Mordes John P, Rossini Aldo A, Greiner Dale L

Abstract excerpt

The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD mice resist peripheral transplantation tolerance induced by costimulation blockade using donor-specific transfusion and anti-CD154 antibody. Hypothesizing that these two abnormalities might be related, we investigated whether they...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12540603
DOI: 10.2337/diabetes.52.2.321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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