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Article

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.

PloS one - 1 Jan 2014

Kochupurakkal Nora M, Kruger Annie J, Tripathi Sudipta, Zhu Bing, Adams La Tonya, Rainbow Daniel B, Rossini Aldo, Greiner Dale L, Sayegh Mohamed H, Wicker Linda S, Guleria Indira

Abstract excerpt

AIMS/HYPOTHESIS: Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular mechanism by which PD1 signaling protects from type 1 diabetes is not clear. We hypothesized that differential susceptibility of Idd mouse strains to type 1 diabetes when challenged with anti PDL1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24586872
DOI: 10.1371/journal.pone.0089561
PMCID: PMC3938467

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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