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Article

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2003

Pearson Todd, Markees Thomas G, Serreze David V, Pierce Melissa A, Marron Michele P, Wicker Linda S, Peterson Laurence B, Shultz Leonard D, Mordes John P, Rossini Aldo A, Greiner Dale L

Abstract excerpt

Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction would be preferable. Most islet allotransplant tolerance induction protocols have been tested in nonobese diabetic (NOD) mice, and most have failed. Failure has been attributed to the underlying autoimmunity, assuming...

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PMID: 12816997
DOI: 10.4049/jimmunol.171.1.185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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