Article
MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2004
Serreze David V, Holl T Matthew, Marron Michele P, Graser Robert T, Johnson Ellis A, Choisy-Rossi Caroline, Slattery Robyn M, Lieberman Scott M, DiLorenzo Teresa P
Abstract excerpt
Development of autoreactive CD4 T cells contributing to type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice is either promoted or dominantly inhibited by particular MHC class II variants. In addition, it is now clear that when co-expressed with other susceptibility genes, some common MHC class I variants aberrantly mediate autoreactive CD8 T cell responses also essential to T1D development....
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