Article
Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice.
Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2001
Hamilton-Williams E E, Serreze D V, Charlton B, Johnson E A, Marron M P, Mullbacher A, Slattery R M
Abstract excerpt
Type 1 diabetes in both humans and nonobese diabetic (NOD) mice results from T-cell-mediated autoimmune destruction of insulin-producing pancreatic beta cells. Linkage studies have shown that type 1 diabetes in NOD mice is a polygenic disease involving more than 15 chromosomal susceptibility regions. Despite extensive investigation, the identification of individual susceptibility genes either within or outside...
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