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Article

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.

Diabetes - 1 Aug 2004

Pearson Todd, Weiser Peter, Markees Thomas G, Serreze David V, Wicker Linda S, Peterson Laurence B, Cumisky Anne-Marie, Shultz Leonard D, Mordes John P, Rossini Aldo A, Greiner Dale L

Abstract excerpt

NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant resistance to transplantation tolerance induction. These two phenotypes are genetically separable. Costimulation blockade fails to prolong skin allograft survival in (NOD x C57BL/6)F1 mice and in NOD-related strains made diabetes-resistant by congenic introduction of protective major histocompatibility complex (MHC) or non-MHC Idd region...

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Identifiers

PMID: 15277375
DOI: 10.2337/diabetes.53.8.1972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.PMID 15277375Read ↗

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