Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevention of type 1 diabetes by gene therapy

1 Oct 2004

Abstract excerpt

The autoimmune disease type 1 diabetes in humans and NOD mice is determined by multiple genetic factors, among the strongest of which is the inheritance of diabetes-permissive MHC class II alleles associated with susceptibility to disease. Here we examined whether expression of MHC class II alleles associated with resistance to disease could be used to prevent the occurrence of diabetes. Expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Immune Cell Function and Interaction
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15467836
DOI: 10.1172/jci22103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevention of type 1 diabetes by gene therapyPMID 15467836Read ↗

Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy.Semantic proximity Read ↗

Reduction in diabetes incidence in an I-Ag7 transgenic nonobese diabetic mouse line.Semantic proximity Read ↗

Understanding autoimmune diabetes: insights from mouse models.Semantic proximity Read ↗

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.Semantic proximity Read ↗

Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans.Semantic proximity Read ↗

Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice.Semantic proximity Read ↗

Genetic and Pharmacologic Models for Type 1 DiabetesSemantic proximity Read ↗

MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.Semantic proximity Read ↗

Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice.Semantic proximity Read ↗

Prevention of type 1 diabetes with major histocompatibility complex-compatible and nonmarrow ablative hematopoietic stem cell transplants.Semantic proximity Read ↗

IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.Semantic proximity Read ↗

Gene therapy for diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.