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Article

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2006

Takaki Toshiyuki, Marron Michele P, Mathews Clayton E, Guttmann Stephen T, Bottino Rita, Trucco Massimo, DiLorenzo Teresa P, Serreze David V

Abstract excerpt

In both humans and NOD mice, particular MHC genes are primary contributors to development of the autoreactive CD4+ and CD8+ T cell responses against pancreatic beta cells that cause type 1 diabetes (T1D). Association studies have suggested, but not proved, that the HLA-A*0201 MHC class I variant is an important contributor to T1D in humans. In this study, we show that transgenic expression in NOD mice of...

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Identifiers

PMID: 16493087
DOI: 10.4049/jimmunol.176.5.3257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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