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Article

Parental transmission of HLA-DRB1*15 in multiple sclerosis.

Human genetics - 1 Jan 2008

Ramagopalan Sreeram V, Herrera Blanca M, Bell Jordana T, Dyment David A, Deluca Gabriele C, Lincoln Matthew R, Orton Sarah M, Chao Michael J, Sadovnick A Dessa, Ebers George C

Abstract excerpt

Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB1*15 haplotypes stratified by sex of transmitting parent. A significant over transmission of...

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Identifiers

PMID: 17972102
DOI: 10.1007/s00439-007-0442-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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