Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MHC transmission: insights into gender bias in MS susceptibility.

Neurology - 18 Jan 2011

Chao M J, Ramagopalan S V, Herrera B M, Orton S M, Handunnetthi L, Lincoln M R, Dyment D A, Sadovnick A D, Ebers G C

Abstract excerpt

OBJECTIVE: Major histocompatibility complex (MHC) genes dominate genetic susceptibility factors in multiple sclerosis (MS). Given the general consensus that incidence and prevalence of MS has been rising and specifically in women, we evaluated MHC-gender interactions. METHODS: In a large family-based cohort consisting of 7,093 individuals (2,127 affected individuals) from 1,055 MS families, we examined MHC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Epigenesis, Genetic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Major Histocompatibility Complex

Share to Multiple Sclerosis

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21209377
DOI: 10.1212/WNL.0b013e318207b060
PMCID: PMC3034390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MHC transmission: insights into gender bias in MS susceptibility.PMID 21209377Read ↗

HLA-DRB1*15:01 and multiple sclerosis: a female association?Semantic proximity Read ↗

Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex.Semantic proximity Read ↗

Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis.Semantic proximity Read ↗

Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.Semantic proximity Read ↗

Parental transmission of HLA-DRB1*15 in multiple sclerosis.Semantic proximity Read ↗

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.Semantic proximity Read ↗

HLA-DRB1*15:01 drives sex- and age-dependent microglial immune phenotypes and neuroimmune signaling.Semantic proximity Read ↗

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.Semantic proximity Read ↗

HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility.Semantic proximity Read ↗

Multiple sclerosis: doubling down on MHCSemantic proximity Read ↗

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.Semantic proximity Read ↗

A genome scan in a single pedigree with a high prevalence of multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.