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Article

The inheritance of resistance alleles in multiple sclerosis.

PLoS genetics - 1 Sept 2007

Ramagopalan Sreeram V, Morris Andrew P, Dyment David A, Herrera Blanca M, DeLuca Gabriele C, Lincoln Matthew R, Orton Sarah M, Chao Michael J, Sadovnick A Dessa, Ebers George C

Abstract excerpt

Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. HLA-DRB1*15 and HLA-DRB1*17-bearing haplotypes and interactions at the HLA-DRB1 locus increase risk of MS but it has taken large samples to identify resistance HLA-DRB1 alleles. In this investigation of 7,093 individuals from 1,432 MS families, we have assessed...

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Source

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Identifiers

PMID: 17845076
DOI: 10.1371/journal.pgen.0030150
PMCID: PMC1971120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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