Article
A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
PloS one - 25 Jun 2010
Cree Bruce A C, Rioux John D, McCauley Jacob L, Gourraud Pierre-Antoine F D, Goyette Philippe, McElroy Joseph, De Jager Philip, Santaniello Adam, Vyse Timothy J, Gregersen Peter K, Mirel Daniel, Hafler David A, Haines Jonathan L, Pericak-Vance Margaret A, Compston Alastair, Sawcer Stephen J, Oksenberg Jorge R, Hauser Stephen L
Abstract excerpt
BACKGROUND: In Northern European descended populations, genetic susceptibility for multiple sclerosis (MS) is associated with alleles of the human leukocyte antigen (HLA) Class II gene DRB1. Whether other major histocompatibility complex (MHC) genes contribute to MS susceptibility is controversial. METHODOLOGY/PRINCIPAL FINDINGS: A case control analysis was performed using 958 single nucleotide polymorphisms...
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