Article
HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility.
Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2008
Chao Michael J, Barnardo Martin C N M, Lincoln Matthew R, Ramagopalan Sreeram V, Herrera Blanca M, Dyment David A, Montpetit Alexandre, Sadovnick A Dessa, Knight Julian C, Ebers George C
Abstract excerpt
The major locus for multiple sclerosis (MS) susceptibility is located within the class II region of the Major Histocompatibility Complex (MHC). HLA-DRB1 alleles, constituting the strongest MS susceptibility factors, have been widely exploited in research including construction of transgenic animal models of MS. Many studies have concluded that HLA-DRB1*15 allele itself determines MS-associated susceptibility. If...
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