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Article

A genome scan in a single pedigree with a high prevalence of multiple sclerosis.

Journal of neurology, neurosurgery, and psychiatry - 1 Feb 2008

Dyment D A, Cader M Z, Herrera B M, Ramagopalan S V, Orton S M, Chao M, Willer C J, Sadovnick A D, Risch N, Ebers G C

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is a disease that is widely believed to be autoimmune in nature. Genetic-epidemiological studies implicate susceptibility genes in the pathogenesis of MS, although non-MHC susceptibility linkages have been difficult to confirm. Insight into pathways that are intrinsic to other complex diseases has come from the genetic analysis of large, autosomal-dominant kindreds. Here, we...

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PMID: 17550985
DOI: 10.1136/jnnp.2007.122705

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