Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.

doi:10.1093/hmg/ddi206

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Article

Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.

Human molecular genetics - 15 Jul 2005

Dyment David A, Herrera Blanca M, Cader M Zameel, Willer Cristen J, Lincoln Matthew R, Sadovnick A Dessa, Risch Neil, Ebers George C

Abstract excerpt

Mechanisms for observed associations within the major histocompatibility complex (MHC) and autoimmune diseases including multiple sclerosis (MS) remain uncertain. Genotyping of the HLA Class II DRB1 locus in 4347 individuals from 873 multiplex families with MS highlights the genetic complexity of this locus. Excess allele sharing in sibling pair families lacking DRB1*15 and DRB1*17 (58.5% sharing; P=0.012) was...

Topics

Alleles
Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DRB1 Chains
Haplotypes
Humans
Major Histocompatibility Complex
Multiple Sclerosis

Source

Open in PubMed

Identifiers

PMID: 15930013
DOI: 10.1093/hmg/ddi206

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