Article
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.
Human molecular genetics - 15 Sept 2006
Barcellos Lisa F, Sawcer Stephen, Ramsay Patricia P, Baranzini Sergio E, Thomson Glenys, Briggs Farren, Cree Bruce C A, Begovich Ann B, Villoslada Pablo, Montalban Xavier, Uccelli Antonio, Savettieri Giovanni, Lincoln Robin R, DeLoa Carolyn, Haines Jonathan L, Pericak-Vance Margaret A, Compston Alastair, Hauser Stephen L, Oksenberg Jorge R
Abstract excerpt
Variation in major histocompatibility complex genes on chromosome 6p21.3, specifically the human leukocyte antigen HLA-DR2 or DRB1*1501-DQB1*0602 extended haplotype, confers risk for multiple sclerosis (MS). Previous studies of DRB1 variation and both MS susceptibility and phenotypic expression have lacked statistical power to detect modest genotypic influences, and have demonstrated conflicting results. Results...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Databases, Genetic
- Female
- Genetic Variation
- Genotype
- HLA-DR Antigens
- HLA-DRB1 Chains