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Article

Epistasis between HLA-DRB1 parental alleles in a Spanish cohort with multiple sclerosis.

Journal of the neurological sciences - 15 Nov 2010

Romero-Pinel Lucía, Pujal Josep María, Martínez-Yélamos Sergio, Gubieras Laura, Matas Elisabet, Bau Laura, Torrabadella Marta, Azqueta Carmen, Arbizu Txomin

Abstract excerpt

BACKGROUND AND OBJECTIVE: Multiple sclerosis (MS) has been consistently associated with the HLA-DR2 haplotype and particularly with the HLA-DRB1*15 allele. Epistatic interactions between both parental alleles in the DRB1 loci have been shown to modify the MS susceptibility risk. This study investigated the frequencies of various HLA-DRB1 genotypes, their impact on MS susceptibility and their correlation with the...

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Source

Identifiers

PMID: 20810130
DOI: 10.1016/j.jns.2010.07.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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