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Article

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2009

Lincoln Matthew R, Ramagopalan Sreeram V, Chao Michael J, Herrera Blanca M, Deluca Gabriele C, Orton Sarah-Michelle, Dyment David A, Sadovnick A Dessa, Ebers George C

Abstract excerpt

Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable component. Susceptibility is associated with the MHC class II region, especially HLA-DRB5*0101-HLA-DRB1*1501-HLA-DQA1*0102-HLA-DQB1*0602 haplotypes(hereafter DR2), which dominate genetic contribution to MS risk. Marked linkage disequilibrium (LD) among these loci makes identification of a specific locus difficult....

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Identifiers

PMID: 19380721
DOI: 10.1073/pnas.0812664106
PMCID: PMC2678609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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