Article
Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis.
Human molecular genetics - 15 Sept 2010
Chao Michael J, Herrera Blanca M, Ramagopalan Sreeram V, Deluca Gabriel, Handunetthi Lahiru, Orton Sarah M, Lincoln Matthew R, Sadovnick A Dessa, Ebers George C
Abstract excerpt
Multiple sclerosis (MS) susceptibility is characterized by maternal parent-of-origin effects and increased female penetrance. In 7796 individuals from 1797 MS families (affected individuals n = 2954), we further implicate epigenetic modifications within major histocompatibility complex (MHC) class II haplotypes as mediating these phenomena. Affected individuals with the main MS-associated allele HLA-DRB1*15 had a...
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