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Article

Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex.

Human molecular genetics - 15 Jan 2009

Chao Michael J, Ramagopalan Sreeram V, Herrera Blanca M, Lincoln Matthew R, Dyment David A, Sadovnick A Dessa, Ebers George C

Abstract excerpt

Multiple sclerosis (MS) susceptibility demonstrates a complex pattern of inheritance. Haplotypes containing HLA-DRB1*1501 carry most of the genetic risk. Epidemiological evidence implicating epigenetic factors includes complex distortion of disease transmission seen in aunt/uncle-niece/nephew (AUNN) pairs. Unexpectedly, in AUNN families we found that allele frequencies for HLA-DRB1*1501 were different between the...

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Source

Identifiers

PMID: 19098025
DOI: 10.1093/hmg/ddn353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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