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Article

Different abilities of escape mutant-specific cytotoxic T cells to suppress replication of escape mutant and wild-type human immunodeficiency virus type 1 in new hosts.

Journal of virology - 1 Jan 2008

Fujiwara Mamoru, Tanuma Junko, Koizumi Hirokazu, Kawashima Yuka, Honda Kazutaka, Mastuoka-Aizawa Saori, Dohki Sachi, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

There is much evidence that in human immunodeficiency virus type 1 (HIV-1)-infected individuals, strong cytotoxic T lymphocyte (CTL)-mediated immune pressure results in the selection of HIV-1 mutants that have escaped from wild-type-specific CTLs. If escape mutant-specific CTLs are not elicited in new hosts sharing donor HLA molecules, the transmission of these mutants results in the accumulation of escape...

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Identifiers

PMID: 17959671
DOI: 10.1128/JVI.01452-07
PMCID: PMC2224353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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