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Article

Selection of escape mutant by HLA-C-restricted HIV-1 Pol-specific cytotoxic T lymphocytes carrying strong ability to suppress HIV-1 replication.

European journal of immunology - 1 Jan 2011

Honda Kazutaka, Zheng Nan, Murakoshi Hayato, Hashimoto Masao, Sakai Keiko, Borghan Mohamed Ali, Chikata Takayuki, Koyanagi Madoka, Tamura Yoshiko, Gatanaga Hiroyuki, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

HIV-1 mutants escaping from HLA-A- or HLA-B-restricted CTL have been well studied, but those from HLA-C-restricted CTL have not. Therefore we investigated the ability of HLA-C-restricted CTL to select HIV-1 escape mutants. In the present study, we identified two novel HLA-Cw(*) 1202-restricted Pol-specific CTL epitopes (Pol328-9 and Pol463-10). CTL specific for these epitopes were detected in 25-40% of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to pol Gene Products, Human Immunodeficiency Virus

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Source

Identifiers

PMID: 21182081
DOI: 10.1002/eji.201040841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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