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Article

Role of Escape Mutant-Specific T Cells in Suppression of HIV-1 Replication and Coevolution with HIV-1.

Journal of virology - 15 Sept 2020

Zhang Yu, Kuse Nozomi, Akahoshi Tomohiro, Chikata Takayuki, Gatanaga Hiroyuki, Oka Shinichi, Murakoshi Hayato, Takiguchi Masafumi

Abstract excerpt

The accumulation of HIV-1 escape mutations affects HIV-1 control by HIV-1-specific T cells. Some of these mutations can elicit escape mutant-specific T cells, but it still remains unclear whether they can suppress the replication of HIV-1 mutants. It is known that HLA-B*52:01-restricted RI8 (Gag 275 to 282; RMYSPTSI) is a protective T cell epitope in HIV-1 subtype B-infected Japanese individuals, though 3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32699092
DOI: 10.1128/JVI.01151-20
PMCID: PMC7495385

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