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Article

Selection and accumulation of an HIV-1 escape mutant by three types of HIV-1-specific cytotoxic T lymphocytes recognizing wild-type and/or escape mutant epitopes.

Journal of virology - 1 Feb 2012

Akahoshi Tomohiro, Chikata Takayuki, Tamura Yoshiko, Gatanaga Hiroyuki, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

It is known that cytotoxic T lymphocytes (CTLs) recognizing HIV-1 escape mutants are elicited in HIV-1-infected individuals, but their role in the control of HIV-1 replication remains unclear. We investigated the antiviral ability of CTLs recognizing the HLA-A*24:02-restricted Gag28 -36 (KYKLKHIVW) epitope and/or its escape mutant (KYRLKHIVW) elicited in the early and chronic phases of the infection. Wild-type...

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Share to Epitopes, T-Lymphocyte
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HLA-A24 Antigen

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Share to T-Lymphocytes, Cytotoxic

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Source

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Identifiers

PMID: 22156528
DOI: 10.1128/JVI.06470-11
PMCID: PMC3302409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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