Article
Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.
The Journal of experimental medicine - 1 Sept 1994
Couillin I, Culmann-Penciolelli B, Gomard E, Choppin J, Levy J P, Guillet J G, Saragosti S
Abstract excerpt
Human immunodeficiency virus (HIV) induces strong responses from human histocompatibility leukocyte antigen (HLA) class I-restricted cytotoxic T lymphocytes (CTL). In a previous report we identified an immunodominant region (amino acids 73-144) in the NEF protein that was recognized by CD8+ class...
Topics
- Amino Acid Sequence
- Base Sequence
- Epitopes
- Gene Products, nef
- HIV-1
- HLA-A Antigens
- HLA-A11 Antigen
- HLA-B Antigens
- HLA-B18 Antigen
- Humans
- Molecular Sequence Data
- Mutation
- T-Lymphocytes, Cytotoxic
- nef Gene Products, Human Immunodeficiency Virus