Article
Escape of human immunodeficiency virus from immune control.
Annual review of immunology - 1 Jan 1997
McMichael A J, Phillips R E
Abstract excerpt
Cytotoxic T lymphocytes (CTL) play a crucial role in the attempt to control infection with human immunodeficiency virus (HIV). Variation in epitopes recognized by CTL is common and frequently offers potential escape routes for mutant virus. Proof of escape, however, requires demonstration of incr...
Topics
- Acute Disease
- Amino Acid Sequence
- Antigen Presentation
- CD4-Positive T-Lymphocytes
- HIV Antibodies
- HIV Antigens
- HIV Infections
- HIV-1
- HLA Antigens
- Humans
- Immunodominant Epitopes
- Mutation
- Receptors, Antigen, T-Cell
- T-Lymphocytes, Cytotoxic
- Time Factors