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Article

Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection

11 Sept 2014

Abstract excerpt

BACKGROUND: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. RESULTS: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous...

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PMID: 25212771
DOI: 10.1186/s12977-014-0069-9

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