Article
Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2007
Mithani Suhail K, Taube Janis M, Zhou Shaoyu, Smith Ian M, Koch Wayne M, Westra William H, Califano Joseph A
Abstract excerpt
PURPOSE: To determine the timing of mitochondrial mutations in the progression of head and neck squamous cell carcinoma. EXPERIMENTAL DESIGN: Twenty-three mitochondrial mutations were identified in 12 tumors using a high-throughput mitochondrial sequencing array. Areas of adjacent dysplastic and normal epithelium adjacent to tumors were sequenced using conventional methods for the presence of mutations that...
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