Article
Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 2007
Zhou Shaoyu, Kachhap Sushant, Sun Wenyue, Wu Guojun, Chuang Alice, Poeta Luana, Grumbine Lawson, Mithani Suhail K, Chatterjee Aditi, Koch Wayne, Westra William H, Maitra Anirban, Glazer Chad, Carducci Michael, Sidransky David, McFate Thomas, Verma Ajay, Califano Joseph A
Abstract excerpt
Mitochondrial genomic mutations are found in a variety of human cancers; however, the frequency of mitochondrial DNA (mtDNA) mutations in coding regions remains poorly defined, and the functional effects of mitochondrial mutations found in primary human cancers are not well described. Using MitoChip, we sequenced the whole mitochondrial genome in 83 head and neck squamous cell carcinomas. Forty-one of 83 (49%)...
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