Article
Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer.
Molecular cancer - 13 Dec 2006
Sui Guoping, Zhou Shaoyu, Wang Jean, Canto Marcia, Lee Edward E, Eshleman James R, Montgomery Elizabeth A, Sidransky David, Califano Joseph A, Maitra Anirban
Abstract excerpt
BACKGROUND: Somatic mutations of mitochondrial DNA (mtDNA) are common in many human cancers. We have described an oligonucleotide microarray ("MitoChip") for rapid sequencing of the entire mitochondrial genome (Zhou et al, J Mol Diagn 2006), facilitating the analysis of mtDNA mutations in preneoplastic lesions. We examined 14 precancerous lesions, including seven Barrett esophagus biopsies, with or without...
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