Article
Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2002
Ha Patrick K, Tong Betty C, Westra William H, Sanchez-Cespedes Montserrat, Parrella Paola, Zahurak Marianna, Sidransky David, Califano Joseph A
Abstract excerpt
PURPOSE: Although mitochondrial DNA mutations have been described recently in many different tumor types, the nature and timing of such alterations remain unclear. In an effort to further examine the role of mitochondrial DNA mutations in carcinogenesis, we examined 137 premalignant lesions of the head and neck from 93 patients for DNA alterations in the poly-cytosine tract (C-tract) of the displacement loop,...
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