Article
Significance of somatic mutations and content alteration of mitochondrial DNA in esophageal cancer.
BMC cancer - 18 Apr 2006
Tan Duan-Jun, Chang Julia, Liu Ling-Ling, Bai Ren-Kui, Wang Yu-Fen, Yeh Kun-Tu, Wong Lee-Jun C
Abstract excerpt
BACKGROUND: The roles of mitochondria in energy metabolism, the generation of ROS, aging, and the initiation of apoptosis have implicated their importance in tumorigenesis. In this study we aim to establish the mutation spectrum and to understand the role of somatic mtDNA mutations in esophageal cancer. METHODS: The entire mitochondrial genome was screened for somatic mutations in 20 pairs (18 esophageal squamous...
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