Article
Validation of Next-Generation Sequencing of Entire Mitochondrial Genomes and the Diversity of Mitochondrial DNA Mutations in Oral Squamous Cell Carcinoma.
PloS one - 1 Jan 2015
Kloss-Brandstätter Anita, Weissensteiner Hansi, Erhart Gertraud, Schäfer Georg, Forer Lukas, Schönherr Sebastian, Pacher Dominic, Seifarth Christof, Stöckl Andrea, Fendt Liane, Sottsas Irma, Klocker Helmut, Huck Christian W, Rasse Michael, Kronenberg Florian, Kloss Frank R
Abstract excerpt
BACKGROUND: Oral squamous cell carcinoma (OSCC) is mainly caused by smoking and alcohol abuse and shows a five-year survival rate of ~50%. We aimed to explore the variation of somatic mitochondrial DNA (mtDNA) mutations in primary oral tumors, recurrences and metastases. METHODS: We performed an in-depth validation of mtDNA next-generation sequencing (NGS) on an Illumina HiSeq 2500 platform for its application to...
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