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Mutations in Mitochondrial DNA From Pancreatic Ductal Adenocarcinomas Associate With Survival Times of Patients and Accumulate as Tumors Progress.

Gastroenterology - 1 May 2018

Hopkins Julia F, Denroche Robert E, Aguiar Jennifer A, Notta Faiyaz, Connor Ashton A, Wilson Julie M, Stein Lincoln D, Gallinger Steven, Boutros Paul C

Abstract excerpt

Somatic mutations have been found in the mitochondria in different types of cancer cells, but it is not clear whether these affect tumorigenesis or tumor progression. We analyzed mitochondrial genomes of 268 early-stage, resected pancreatic ductal adenocarcinoma tissues and paired non-tumor tissues. We defined a mitochondrial somatic mutation (mtSNV) as a position where the difference in heteroplasmy fraction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29378198
DOI: 10.1053/j.gastro.2018.01.029

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