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Impact of somatic mutations in the D-loop of mitochondrial DNA on the survival of oral squamous cell carcinoma patients.

PloS one - 1 Jan 2015

Lin Jin-Ching, Wang Chen-Chi, Jiang Rong-San, Wang Wen-Yi, Liu Shih-An

Abstract excerpt

OBJECTIVES: The aim of this study was to investigate somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in oral squamous cell carcinoma patients. MATERIALS AND METHODS: Surgical specimen confirmed by pathological examination and corresponding non-cancerous tissues were collected from 120 oral squamous cell carcinoma patients. The sequence in the D-loop of mtDNA from...

Topics

Adult
Aged
Carcinoma, Squamous Cell
DNA, Mitochondrial
Female
Humans
Male
Middle Aged
Mouth Neoplasms
Mutation
Nucleic Acid Conformation
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Survival Analysis

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Identifiers

PMID: 25906372
DOI: 10.1371/journal.pone.0124322
PMCID: PMC4408030

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