Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility.

British journal of cancer - 12 Apr 2011

Challen C, Brown H, Cai C, Betts G, Paterson I, Sloan P, West C, Birch-Machin M, Robinson M

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) mutations occur in head and neck squamous cell carcinoma (HNSCC) and are most frequently detected in the displacement-loop (D-loop) region. The D-loop is considered to be important because it controls mitochondrial gene expression and mtDNA replication. There is currently no evidence that mtDNA mutations can be used as prognostic or predictive biomarkers in HNSCC. METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Cell Line
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Head and Neck Neoplasms

Share to High-Throughput Nucleotide Sequencing

Share to Predictive Value of Tests

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 21427725
DOI: 10.1038/bjc.2011.96
PMCID: PMC3078603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial DNA mutations in head and neck cancer are infrequent and lack prognostic utility.PMID 21427725Read ↗

The significance of mitochondrial DNA changes during the onset and progression of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.Semantic proximity Read ↗

Somatic mutations in the D-loop of mitochondrial DNA in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Clinicopathological significance of mitochondrial D-Loop mutations in head and neck carcinomaSemantic proximity Read ↗

Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients.Semantic proximity Read ↗

Relationship between mitochondrial DNA instability, mitochondrial DNA large deletions, and nuclear microsatellite instability in head and neck squamous cell carcinomas.Semantic proximity Read ↗

A study of mitochondrial DNA D-loop mutations and p53 status in nonmelanoma skin cancer.Semantic proximity Read ↗

Profiling of genomic alterations of mitochondrial DNA in gingivobuccal oral squamous cell carcinoma: Implications for disease progressSemantic proximity Read ↗

Impact of somatic mutations in the D-loop of mitochondrial DNA on the survival of oral squamous cell carcinoma patients.Semantic proximity Read ↗

Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.Semantic proximity Read ↗

Mitochondrial DNA copy number is associated with diagnosis and prognosis of head and neck cancerSemantic proximity Read ↗

D-loop somatic mutations and ∼5 kb "common" deletion in mitochondrial DNA: important molecular markers to distinguish oral precancer and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.