Article
Somatic mutations in the D-loop of mitochondrial DNA in head and neck squamous cell carcinoma.
Head & neck - 1 Jun 2015
Liu Shih-An, Jiang Rong-San, Wang Wen-Yi, Lin Jin-Ching
Abstract excerpt
BACKGROUND: The purpose of this study was to characterize somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in patients with head and neck cancer. METHODS: Histologically confirmed head and neck cancer and corresponding noncancerous tissues were obtained from 130 patients. The D-loop of mtDNA sequence in noncancerous tissues was compared with that of paired cancer samples...
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