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Somatic mutations in the D-loop of mitochondrial DNA in head and neck squamous cell carcinoma.

Head & neck - 1 Jun 2015

Liu Shih-An, Jiang Rong-San, Wang Wen-Yi, Lin Jin-Ching

Abstract excerpt

BACKGROUND: The purpose of this study was to characterize somatic mutations in the D-loop of mitochondrial DNA (mtDNA) and their impact on survival in patients with head and neck cancer. METHODS: Histologically confirmed head and neck cancer and corresponding noncancerous tissues were obtained from 130 patients. The D-loop of mtDNA sequence in noncancerous tissues was compared with that of paired cancer samples...

Topics

Aged
Analysis of Variance
Carcinoma, Squamous Cell
Cohort Studies
DNA, Mitochondrial
Disease-Free Survival
Female
Head and Neck Neoplasms
Humans
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptides, Cyclic

Predictive Value of Tests

Retrospective Studies

Squamous Cell Carcinoma of Head and Neck

Survival Analysis

Source

Identifiers

PMID: 24976238
DOI: 10.1002/hed.23680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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