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Article

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium.

Human molecular genetics - 15 Aug 2007

Chao Michael J, Barnardo Martin C N M, Lui Guang-Zhi, Lincoln Matthew R, Ramagopalan Sreeram V, Herrera Blanca M, Dyment David A, Sadovnick A Dessa, Ebers George C

Abstract excerpt

The human major histocompatibility complex (MHC) class II region is associated with genetic susceptibility to multiple sclerosis (MS). Roles for HLA class I loci have been supported in several case-control studies, but this methodology does not consider the known linkage disequilibrium (LD) between class I and II loci. In 1258 individuals from 294 MS families, we analysed class I and II interactions. Using...

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PMID: 17584771
DOI: 10.1093/hmg/ddm142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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