Article
High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.
Genes and immunity - 1 Apr 2019
Mack Steven J, Udell Julia, Cohen Franziska, Osoegawa Kazutoyo, Hawbecker Sharon K, Noonan David A, Ladner Martha B, Goodridge Damian, Trachtenberg Elizabeth A, Oksenberg Jorge R, Erlich Henry A
Abstract excerpt
We investigated association between HLA class I and class II alleles and haplotypes, and KIR loci and their HLA class I ligands, with multiple sclerosis (MS) in 412 European American MS patients and 419 ethnically matched controls, using next-generation sequencing. The DRB1*15:01~DQB1*06:02 haplotype was highly predisposing (odds ratio (OR) = 3.98; 95% confidence interval (CI) = 3-5.31; p-value (p) = 2.22E-16),...
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