Article
Class II HLA interactions modulate genetic risk for multiple sclerosis.
Nature genetics - 1 Oct 2015
Moutsianas Loukas, Jostins Luke, Beecham Ashley H, Dilthey Alexander T, Xifara Dionysia K, Ban Maria, Shah Tejas S, Patsopoulos Nikolaos A, Alfredsson Lars, Anderson Carl A, Attfield Katherine E, Baranzini Sergio E, Barrett Jeffrey, Binder Thomas M C, Booth David, Buck Dorothea, Celius Elisabeth G, Cotsapas Chris, D'Alfonso Sandra, Dendrou Calliope A, Donnelly Peter, Dubois Bénédicte, Fontaine Bertrand, Fugger Lars, Goris An, Gourraud Pierre-Antoine, Graetz Christiane, Hemmer Bernhard, Hillert Jan, Kockum Ingrid, Leslie Stephen, Lill Christina M, Martinelli-Boneschi Filippo, Oksenberg Jorge R, Olsson Tomas, Oturai Annette, Saarela Janna, Søndergaard Helle Bach, Spurkland Anne, Taylor Bruce, Winkelmann Juliane, Zipp Frauke, Haines Jonathan L, Pericak-Vance Margaret A, Spencer Chris C A, Stewart Graeme, Hafler David A, Ivinson Adrian J, Harbo Hanne F, Hauser Stephen L, De Jager Philip L, Compston Alastair, McCauley Jacob L, Sawcer Stephen, McVean Gil
Abstract excerpt
Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA...
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