Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis

doi:10.1177/1352458518770019

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Article

Deconstruction of HLA-DRB104:01:01 and HLA-DRB115:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis

23 Apr 2018

Abstract excerpt

BACKGROUND: The association between HLA-DRB1*15:01 with multiple sclerosis (MS) susceptibility is well established, but the contribution of the tightly associated HLA-DRB5*01:01 allele has not yet been completely ascertained. Similarly, the effects of HLA-DRB1*04:01 alleles and haplotypes, defined at the full-gene resolution level with MS risk remains to be elucidated. OBJECTIVES: To characterize the molecular...

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PMID: 29683085
DOI: 10.1177/1352458518770019

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