Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis.

PloS one - 1 Jan 2012

Link Jenny, Kockum Ingrid, Lorentzen Aslaug R, Lie Benedicte A, Celius Elisabeth G, Westerlind Helga, Schaffer Marie, Alfredsson Lars, Olsson Tomas, Brynedal Boel, Harbo Hanne F, Hillert Jan

Abstract excerpt

Multiple sclerosis (MS) is a complex disease of the central nervous system of unknown etiology. The human leukocyte antigen (HLA) locus on chromosome 6 confers a considerable part of the susceptibility to MS, and the most important factor is the class II allele HLA-DRB1*15:01. In addition, we and others have previously established a protective effect of HLA-A*02. Here, we genotyped 1,784 patients and 1,660...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Haplotypes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-A Antigens

Share to HLA-B Antigens

Share to HLA-DRB1 Chains

Share to Linkage Disequilibrium

Share to Multiple Sclerosis

Share to Scandinavian and Nordic Countries

Source

Open in PubMed Open full text

Identifiers

PMID: 22586495
DOI: 10.1371/journal.pone.0036779
PMCID: PMC3346735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis.PMID 22586495Read ↗

Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease.Semantic proximity Read ↗

Human leucocyte antigen (HLA) class I and II typing in Belgian multiple sclerosis patients.Semantic proximity Read ↗

Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosisSemantic proximity Read ↗

HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis.Semantic proximity Read ↗

Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis.Semantic proximity Read ↗

HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility.Semantic proximity Read ↗

Relationship between HLA-DRB1* 11/15 genotype and susceptibility to multiple sclerosis in Iran.Semantic proximity Read ↗

Epistasis between HLA-DRB1 parental alleles in a Spanish cohort with multiple sclerosis.Semantic proximity Read ↗

Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.Semantic proximity Read ↗

A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.Semantic proximity Read ↗

HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.Semantic proximity Read ↗

Genetic factors and multiple sclerosis in the Moroccan population: a role for HLA class II.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.