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Article

HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis.

PloS one - 25 Jul 2007

Brynedal Boel, Duvefelt Kristina, Jonasdottir Gudrun, Roos Izaura M, Akesson Eva, Palmgren Juni, Hillert Jan

Abstract excerpt

A recent high-density linkage screen confirmed that the HLA complex contains the strongest genetic factor for the risk of multiple sclerosis (MS). In parallel, a linkage disequilibrium analysis using 650 single nucleotide polymorphisms (SNP) markers of the HLA complex mapped the entire genetic effect to the HLA-DR-DQ subregion, reflected by the well-established risk haplotype HLA-DRB1*15,DQB1*06. Contrary to...

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Source

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Identifiers

PMID: 17653284
DOI: 10.1371/journal.pone.0000664
PMCID: PMC1919434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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