Article
Evidence of linkage with HLA-DR in DRB1*15-negative families with multiple sclerosis.
American journal of human genetics - 1 Oct 2001
Ligers A, Dyment D A, Willer C J, Sadovnick A D, Ebers G, Risch N, Hillert J
Abstract excerpt
The importance of the HLA-DR locus to multiple sclerosis (MS) susceptibility was assessed in 542 sib pairs with MS and in their families. By genotyping 1,978 individuals for HLA-DRB1 alleles, we confirmed the well-established association of MS with HLA-DRB1*15 (HLA-DRB1*1501 and HLA-DRB5*0101), by the transmission/disequilibrium test (chi2=138.3; P<.0001). We obtained significant evidence of linkage throughout...
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