Article
Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals.
Molecular immunology - 1 Jan 2008
Ramasawmy Rajendranath, Faé Kellen C, Cunha-Neto Edecio, Borba Susan C P, Ianni Barbara, Mady Charles, Goldberg Anna C, Kalil Jorge
Abstract excerpt
Chagas' disease, caused by Trypanosoma cruzi, is an inflammatory disorder leading to chronic Chagas cardiomyopathy (CCC). Only one third of T. cruzi-infected individuals progress to CCC while the others are considered asymptomatic (ASY). The human inhibitory kappaB-like gene (IKBL/NFKBIL1), homologous to the IkappaB family of proteins that regulate the NFkappaB family of transcription factors, is suggested as a...
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