Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy.

doi:10.3389/fimmu.2020.01386

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Article

Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy.

Frontiers in immunology - 1 Jan 2020

Frade-Barros Amanda Farage, Ianni Barbara Maria, Cabantous Sandrine, Pissetti Cristina Wide, Saba Bruno, Lin-Wang Hui Tzu, Buck Paula, Marin-Neto José Antonio, Schmidt André, Dias Fabrício, Hirata Mario Hiroyuki, Sampaio Marcelo, Fragata Abílio, Pereira Alexandre Costa, Donadi Eduardo, Rodrigues Virmondes, Kalil Jorge, Chevillard Christophe, Cunha-Neto Edecio

Abstract excerpt

Background: Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America. Thirty percent of infected individuals develop chronic Chagas cardiomyopathy (CCC), an inflammatory dilated cardiomyopathy that is the most important clinical consequence of T. cruzi infection, while the others remain asymptomatic (ASY). IFN-γ and IFN-γ-producing Th1-type T cells are increased in peripheral blood...

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PMID: 32733459
DOI: 10.3389/fimmu.2020.01386
PMCID: PMC7358543

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